{ "title": "How Heat Meds performs on the 300 most-prescribed US medicines", "run_on": "2026-09-30T21:40:23.785Z", "commit": "5f1ff4b", "commit_clean": true, "rules_version": "1.0.0", "test_set": { "title": "The 300 most-prescribed US medicines, by ingredient", "source": { "title": "AHRQ Medical Expenditure Panel Survey, HC-254A: 2024 Prescribed Medicines File (public domain)", "url": "https://meps.ahrq.gov/mepsweb/data_stats/download_data_files_detail.jsp?cboPufNumber=HC-254A", "layout": "https://meps.ahrq.gov/data_stats/download_data/pufs/h254a/h254aru.txt" }, "count": 300, "derived_on": "2026-09-30", "method": [ "Each MEPS record is one household-reported prescription fill in 2024. Fills whose drug name MEPS masked with a therapeutic-class placeholder (RXNDC = -15) were dropped.", "Fills were grouped by RXDRGNAM (the MEPS normalized drug name) and weighted by PERWT24F, the full-year person weight, so each fill counts for the people it represents nationally.", "The 428 highest-weight names were resolved to RxNorm ingredients with the same rxnorm.js module the site uses. A combination product credits its full weight to each ingredient. Precise ingredients (for example metoprolol succinate) were merged into their base ingredient.", "Ingredients were ranked by total weight and the top 300 kept. Weighted fills are rounded." ] }, "answer_keys": { "ukhsa": { "title": "UK Health Security Agency, Supporting vulnerable people before and during hot weather: healthcare professionals", "url": "https://www.gov.uk/guidance/supporting-vulnerable-people-before-and-during-hot-weather-healthcare-professionals", "phrases": [ { "phrase": "diuretics, especially loop diuretics, which can lead to dehydration and electrolyte abnormalities", "atc_prefixes": [ "C03" ], "ingredients": [], "reason": "All diuretics (C03); UKHSA singles out loop diuretics but names diuretics as the class." }, { "phrase": "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs", "atc_prefixes": [ "C02", "C07", "C08", "C09", "C01DA" ], "ingredients": [], "reason": "Antihypertensives read as the ATC blood-pressure groups C02, C07, C08, C09; antianginals as nitrates C01DA. Narrower reading: diuretics are counted under the diuretics phrase, not here; C01 antiarrhythmics and cardiac glycosides are excluded." }, { "phrase": "medications that interfere with sweating, such as anticholinergics or beta blockers", "atc_prefixes": [ "C07", "N04A", "A03B", "G04BD", "R06AA", "R06AD" ], "ingredients": [ "diphenhydramine", "doxylamine", "promethazine", "hydroxyzine", "oxybutynin", "tolterodine", "solifenacin", "benztropine", "trihexyphenidyl", "scopolamine", "amitriptyline", "nortriptyline", "imipramine", "clomipramine", "doxepin" ], "reason": "Beta blockers C07. Anticholinergics read narrowly as classes whose main action is anticholinergic: anticholinergic antiparkinson agents N04A, gut antispasmodics A03B, urinary antispasmodics G04BD, first-generation antihistamines by name, and tricyclics by name. Antipsychotics are not counted here; they fall under thermoregulation below." }, { "phrase": "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration", "atc_prefixes": [ "N02A", "J01" ], "ingredients": [ "colchicine" ], "reason": "Opiates N02A, colchicine by name, and antibacterials J01. Narrower reading: antifungals and antivirals are not antibiotics in the everyday sense and are excluded." }, { "phrase": "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies", "atc_prefixes": [ "M01A", "L04A", "L01", "A02B" ], "ingredients": [ "aspirin" ], "reason": "NSAIDs M01A plus aspirin by name, immunosuppressants L04A, antineoplastics L01, anti-ulcer agents A02B (proton pump inhibitors and H2 blockers). Narrower reading: 'certain antimicrobials' is too vague to map beyond the J01 already counted above." }, { "phrase": "agents with levels affected by dehydration, such as lithium, digoxin, antiepileptics", "atc_prefixes": [ "N05AN", "C01AA", "N03A" ], "ingredients": [ "lithium", "digoxin" ], "reason": "Lithium N05AN, digoxin C01AA, antiepileptics N03A. Gabapentin and pregabalin are N03AX and are therefore counted; noted because they are very common and mostly prescribed for pain." }, { "phrase": "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics", "atc_prefixes": [ "N05B", "N05C", "N02A" ], "ingredients": [], "reason": "Anxiolytics N05B, hypnotics N05C, and analgesics read narrowly as opioids N02A (already counted). Narrower reading: non-opioid painkillers such as acetaminophen do not alter alertness and are excluded." }, { "phrase": "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists", "atc_prefixes": [ "N05A", "N06AB", "N06AX", "N02CC" ], "ingredients": [ "venlafaxine", "duloxetine", "desvenlafaxine", "levomilnacipran", "trazodone", "buspirone" ], "reason": "Neuroleptics N05A (minus lithium, counted separately); serotoninergic agonists read as SSRIs N06AB, SNRIs and other serotonergic antidepressants N06AX and by name, and triptans N02CC. Narrower reading: tricyclics are counted under sweating, not here." }, { "phrase": "drugs that increase the basal metabolic rate such as thyroxine", "atc_prefixes": [ "H03AA" ], "ingredients": [ "levothyroxine", "liothyronine" ], "reason": "Thyroid hormones H03AA." } ] }, "health_canada": { "title": "Health Canada, Extreme heat and human health: For pharmacists and pharmacist technicians", "url": "https://www.canada.ca/en/health-canada/services/publications/healthy-living/extreme-heat-human-health-pharmacists-technicians.html", "phrases": [ { "phrase": "Antipsychotics/ Neuroleptics", "atc_prefixes": [ "N05A" ], "ingredients": [], "reason": "Antipsychotics N05A. Lithium (N05AN) is listed separately by Health Canada and counted under its own phrase." }, { "phrase": "Antidepressants", "atc_prefixes": [ "N06A" ], "ingredients": [], "reason": "All antidepressants N06A: SSRIs, SNRIs, tricyclics, and others such as bupropion, mirtazapine, and trazodone. Health Canada gives no narrower class." }, { "phrase": "Lithium", "atc_prefixes": [ "N05AN" ], "ingredients": [ "lithium" ], "reason": "Lithium N05AN." }, { "phrase": "Anti-epileptics", "atc_prefixes": [ "N03A" ], "ingredients": [], "reason": "Antiepileptics N03A, which includes gabapentin and pregabalin (N03AX) even when prescribed for pain." }, { "phrase": "Anti-Alzheimer's agents (Cholinesterase inhibitors)", "atc_prefixes": [ "N06DA" ], "ingredients": [ "donepezil", "rivastigmine", "galantamine" ], "reason": "Cholinesterase inhibitors N06DA. Narrower reading: memantine (N06DX) is an anti-Alzheimer agent but not a cholinesterase inhibitor, which Health Canada specifies in parentheses, so it is excluded." }, { "phrase": "Anti-Parkinson's agents", "atc_prefixes": [ "N04" ], "ingredients": [], "reason": "All antiparkinson agents N04, anticholinergic and dopaminergic." }, { "phrase": "Diuretics", "atc_prefixes": [ "C03" ], "ingredients": [], "reason": "All diuretics C03." }, { "phrase": "Nitrate vasodilators", "atc_prefixes": [ "C01DA" ], "ingredients": [], "reason": "Organic nitrates C01DA." }, { "phrase": "ACE inhibitors", "atc_prefixes": [ "C09A", "C09B" ], "ingredients": [], "reason": "ACE inhibitors plain (C09A) and in combinations (C09B). Narrower reading: ARBs (C09C, C09D) are not named by Health Canada and are excluded." }, { "phrase": "Calcium channel blockers & beta blockers", "atc_prefixes": [ "C08", "C07" ], "ingredients": [], "reason": "Calcium channel blockers C08 and beta blockers C07." } ] }, "ansm": { "key": "ansm", "title": "ANSM (France), Bon usage des medicaments en cas de vague de chaleur", "url": "https://ansm.sante.fr/dossiers-thematiques/conditions-climatiques-extremes-et-produits-de-sante/medicaments-et-fortes-chaleurs", "checked_on": "2026-09-30", "scored": false, "why_not_scored": "The ANSM list is much broader than the CDC, UKHSA, or Health Canada lists; it includes, for example, statins and many other classes reviewed for other reasons. Scoring against it would swamp the comparison. It is shown only as context in the 'i' panel.", "context_note": "France's medicines agency recommends reviewing a wide range of medicines during heat waves, including diuretics, NSAIDs, ACE inhibitors and ARBs, antipsychotics, antidepressants, lithium, antiepileptics, and others. The exact list is on the ANSM page above and is not reproduced or mapped here.", "phrases": [] } }, "must_be_zero": { "flags_without_cdc_quote": 0, "stop_instructions": 0, "stop_examples": [] }, "flags_outside_uk_and_canada": { "count": 18, "medicines": [ { "ingredient": "dextroamphetamine", "rank": 17, "cdc": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ] }, { "ingredient": "amphetamine", "rank": 18, "cdc": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ] }, { "ingredient": "acetaminophen", "rank": 19, "cdc": [ { "id": "acetaminophen", "label": "Acetaminophen", "quote": "Heat related liver injury increase risk for acetaminophen hepatoxicity" } ] }, { "ingredient": "apixaban", "rank": 28, "cdc": [ { "id": "apixaban", "label": "Apixaban (mentioned in the page text, not the table)", "quote": "Toxicity from reduced clearance of medications with a narrow therapeutic index (e.g., apixaban, carbamazepine, and lithium)" } ] }, { "ingredient": "methylphenidate", "rank": 37, "cdc": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ] }, { "ingredient": "clopidogrel", "rank": 50, "cdc": [ { "id": "antiplatelets", "label": "Anti-platelet medications", "quote": "Reduced superficial vasodilation" } ] }, { "ingredient": "lisdexamfetamine", "rank": 76, "cdc": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ] }, { "ingredient": "docusate", "rank": 149, "cdc": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ] }, { "ingredient": "dexmethylphenidate", "rank": 151, "cdc": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ] }, { "ingredient": "magnesium oxide", "rank": 177, "cdc": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ] }, { "ingredient": "sacubitril", "rank": 192, "cdc": [ { "id": "arni", "label": "Angiotensin Receptor-Neprilysin Inhibitors (ARNIs), combination drug including ARB", "quote": "See ARBs. Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) may carry the same additive risk." } ] }, { "ingredient": "polyethylene glycols", "rank": 208, "cdc": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ] }, { "ingredient": "linaclotide", "rank": 218, "cdc": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ] }, { "ingredient": "calcium carbonate", "rank": 232, "cdc": [ { "id": "antacids", "label": "Antacids (mentioned in the page text, not the table)", "quote": "Electrolyte imbalance (e.g., diuretics, beta blockers, calcium channel blockers, antacids, laxatives, lithium, and trimethoprim-sulfamethoxazole)" } ] }, { "ingredient": "sennosides, USP", "rank": 244, "cdc": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ] }, { "ingredient": "ticagrelor", "rank": 246, "cdc": [ { "id": "antiplatelets", "label": "Anti-platelet medications", "quote": "Reduced superficial vasodilation" } ] }, { "ingredient": "lactulose", "rank": 294, "cdc": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ] }, { "ingredient": "magnesium sulfate", "rank": 297, "cdc": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ] } ] }, "agreement": { "ukhsa": { "agree": 225, "total": 300, "rate": 0.75, "app_only": 18, "key_only": 57 }, "health_canada": { "agree": 247, "total": 300, "rate": 0.8233333333333334, "app_only": 43, "key_only": 10 } }, "counts": { "resolved": 300, "unresolved": 0, "app_flagged": 87, "ukhsa_listed": 126, "health_canada_listed": 54, "resolved_without_atc": 15, "resolved_without_atc_names": [ "vilanterol", "clavulanate", "norgestimate", "thyroid (USP)", "insulin isophane", "nirmatrelvir", "sacubitril", "lipase", "protease", "butalbital", "norelgestromin", "levalbuterol", "mycophenolate mofetil", "norgestrel", "carbidopa" ] }, "disagreements": [ { "ingredient": "levothyroxine", "rank": 3, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Thyroid replacement: Levothyroxine. Health Canada does not name this class.", "atc": [ "H03AA" ] }, { "ingredient": "losartan", "rank": 6, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Angiotensin II Receptor blockers (ARBs). Health Canada does not name this class.", "atc": [ "C09CA" ] }, { "ingredient": "omeprazole", "rank": 11, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "A02BC" ] }, { "ingredient": "dextroamphetamine", "rank": 17, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. UK Health Security Agency does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "dextroamphetamine", "rank": 17, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. Health Canada does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "amphetamine", "rank": 18, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. UK Health Security Agency does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "amphetamine", "rank": 18, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. Health Canada does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "acetaminophen", "rank": 19, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Acetaminophen. UK Health Security Agency does not name this class.", "atc": [ "N02BE" ] }, { "ingredient": "acetaminophen", "rank": 19, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Acetaminophen. Health Canada does not name this class.", "atc": [ "N02BE" ] }, { "ingredient": "pantoprazole", "rank": 20, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "A02BC" ] }, { "ingredient": "bupropion", "rank": 21, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists\". The CDC table does not include this class.", "atc": [ "N06AX" ] }, { "ingredient": "bupropion", "rank": 21, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Antidepressants\". The CDC table does not include this class.", "atc": [ "N06AX" ] }, { "ingredient": "amoxicillin", "rank": 22, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01CA" ] }, { "ingredient": "trazodone", "rank": 25, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists\". The CDC table does not include this class.", "atc": [ "N06AX" ] }, { "ingredient": "trazodone", "rank": 25, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Antidepressants\". The CDC table does not include this class.", "atc": [ "N06AX" ] }, { "ingredient": "apixaban", "rank": 28, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Apixaban (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "B01AF" ] }, { "ingredient": "apixaban", "rank": 28, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Apixaban (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "B01AF" ] }, { "ingredient": "oxycodone", "rank": 31, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Opiates (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "N02AA" ] }, { "ingredient": "meloxicam", "rank": 34, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "M01AC" ] }, { "ingredient": "methylphenidate", "rank": 37, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. UK Health Security Agency does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "methylphenidate", "rank": 37, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. Health Canada does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "famotidine", "rank": 41, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "A02BA" ] }, { "ingredient": "ibuprofen", "rank": 42, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "C01EB", "G02CC", "M01AE", "M02AA", "R02AX" ] }, { "ingredient": "buspirone", "rank": 43, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics\". The CDC table does not include this class.", "atc": [ "N05BE" ] }, { "ingredient": "tramadol", "rank": 47, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Opiates (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "N02AX" ] }, { "ingredient": "hydroxyzine", "rank": 49, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with sweating, such as anticholinergics or beta blockers\". The CDC table does not include this class.", "atc": [ "N05BB" ] }, { "ingredient": "clopidogrel", "rank": 50, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Anti-platelet medications. UK Health Security Agency does not name this class.", "atc": [ "B01AC" ] }, { "ingredient": "clopidogrel", "rank": 50, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Anti-platelet medications. Health Canada does not name this class.", "atc": [ "B01AC" ] }, { "ingredient": "valsartan", "rank": 53, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Angiotensin II Receptor blockers (ARBs). Health Canada does not name this class.", "atc": [ "C09CA" ] }, { "ingredient": "zolpidem", "rank": 59, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics\". The CDC table does not include this class.", "atc": [ "N05CF" ] }, { "ingredient": "lamotrigine", "rank": 60, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"agents with levels affected by dehydration, such as lithium, digoxin, antiepileptics\". The CDC table does not include this class.", "atc": [ "N03AX" ] }, { "ingredient": "lamotrigine", "rank": 60, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Anti-epileptics\". The CDC table does not include this class.", "atc": [ "N03AX" ] }, { "ingredient": "alprazolam", "rank": 61, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Benzodiazepines (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "N05BA" ] }, { "ingredient": "aspirin", "rank": 63, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Aspirin. Health Canada does not name this class.", "atc": [ "A01AD", "B01AC", "N02BA" ] }, { "ingredient": "azithromycin", "rank": 68, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01FA", "S01AA" ] }, { "ingredient": "diclofenac", "rank": 73, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "D11AX", "M01AB", "M02AA", "S01BC" ] }, { "ingredient": "lisdexamfetamine", "rank": 76, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. UK Health Security Agency does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "lisdexamfetamine", "rank": 76, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. Health Canada does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "doxycycline", "rank": 78, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "A01AB", "J01AA" ] }, { "ingredient": "lorazepam", "rank": 82, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Benzodiazepines (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "N05BA" ] }, { "ingredient": "celecoxib", "rank": 85, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "L01XX", "M01AH" ] }, { "ingredient": "clonidine", "rank": 88, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs\". The CDC table does not include this class.", "atc": [ "C02AC", "N02CX", "S01EA" ] }, { "ingredient": "cephalexin", "rank": 90, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01DB" ] }, { "ingredient": "olmesartan", "rank": 96, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Angiotensin II Receptor blockers (ARBs). Health Canada does not name this class.", "atc": [ "C09CA" ] }, { "ingredient": "trimethoprim", "rank": 111, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01EA" ] }, { "ingredient": "sumatriptan", "rank": 114, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists\". The CDC table does not include this class.", "atc": [ "N02CC" ] }, { "ingredient": "esomeprazole", "rank": 116, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "A02BC" ] }, { "ingredient": "mirtazapine", "rank": 118, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists\". The CDC table does not include this class.", "atc": [ "N06AX" ] }, { "ingredient": "mirtazapine", "rank": 118, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Antidepressants\". The CDC table does not include this class.", "atc": [ "N06AX" ] }, { "ingredient": "levetiracetam", "rank": 119, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"agents with levels affected by dehydration, such as lithium, digoxin, antiepileptics\". The CDC table does not include this class.", "atc": [ "N03AX" ] }, { "ingredient": "levetiracetam", "rank": 119, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Anti-epileptics\". The CDC table does not include this class.", "atc": [ "N03AX" ] }, { "ingredient": "naproxen", "rank": 120, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "G02CC", "M01AE", "M02AA" ] }, { "ingredient": "hydralazine", "rank": 125, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs\". The CDC table does not include this class.", "atc": [ "C02DB" ] }, { "ingredient": "adalimumab", "rank": 129, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "L04AB" ] }, { "ingredient": "oxybutynin", "rank": 133, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with sweating, such as anticholinergics or beta blockers\". The CDC table does not include this class.", "atc": [ "G04BD" ] }, { "ingredient": "clindamycin", "rank": 135, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "D10AF", "G01AA", "J01FF" ] }, { "ingredient": "irbesartan", "rank": 137, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Angiotensin II Receptor blockers (ARBs). Health Canada does not name this class.", "atc": [ "C09CA" ] }, { "ingredient": "nitrofurantoin", "rank": 140, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01XE" ] }, { "ingredient": "sulfamethoxazole", "rank": 141, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Antibiotics: Sulfonamides. Health Canada does not name this class.", "atc": [ "J01EC" ] }, { "ingredient": "ciprofloxacin", "rank": 147, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01MA", "S01AE", "S02AA", "S03AA" ] }, { "ingredient": "docusate", "rank": 149, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A06AA" ] }, { "ingredient": "docusate", "rank": 149, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A06AA" ] }, { "ingredient": "dexmethylphenidate", "rank": 151, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. UK Health Security Agency does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "dexmethylphenidate", "rank": 151, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Stimulants. Health Canada does not name this class.", "atc": [ "N06BA" ] }, { "ingredient": "promethazine", "rank": 152, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Antihistamines with anticholinergic properties. Health Canada does not name this class.", "atc": [ "D04AA", "R06AD" ] }, { "ingredient": "methotrexate", "rank": 153, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "L01BA", "L04AX" ] }, { "ingredient": "donepezil", "rank": 154, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Anti-Alzheimer's agents (Cholinesterase inhibitors)\". The CDC table does not include this class.", "atc": [ "N06DA" ] }, { "ingredient": "ropinirole", "rank": 156, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Anti-Parkinson's agents\". The CDC table does not include this class.", "atc": [ "N04BC" ] }, { "ingredient": "ofloxacin", "rank": 158, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01MA", "S01AE", "S02AA" ] }, { "ingredient": "metronidazole", "rank": 164, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "A01AB", "D06BX", "G01AF", "J01XD", "P01AB" ] }, { "ingredient": "prazosin", "rank": 165, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs\". The CDC table does not include this class.", "atc": [ "C02CA" ] }, { "ingredient": "diazepam", "rank": 173, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Benzodiazepines (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "N05BA" ] }, { "ingredient": "cefdinir", "rank": 176, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01DD" ] }, { "ingredient": "magnesium oxide", "rank": 177, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A02AA", "A06AD", "A12CC" ] }, { "ingredient": "magnesium oxide", "rank": 177, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A02AA", "A06AD", "A12CC" ] }, { "ingredient": "cyclosporine", "rank": 180, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "L04AD", "S01XA" ] }, { "ingredient": "tretinoin", "rank": 181, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "D10AD", "L01XF" ] }, { "ingredient": "temazepam", "rank": 188, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Benzodiazepines (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "N05CD" ] }, { "ingredient": "sacubitril", "rank": 192, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Angiotensin Receptor-Neprilysin Inhibitors (ARNIs), combination drug including ARB. UK Health Security Agency does not name this class.", "atc": [] }, { "ingredient": "sacubitril", "rank": 192, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Angiotensin Receptor-Neprilysin Inhibitors (ARNIs), combination drug including ARB. Health Canada does not name this class.", "atc": [] }, { "ingredient": "valproate", "rank": 193, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"agents with levels affected by dehydration, such as lithium, digoxin, antiepileptics\". The CDC table does not include this class.", "atc": [ "N03AG" ] }, { "ingredient": "valproate", "rank": 193, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Anti-epileptics\". The CDC table does not include this class.", "atc": [ "N03AG" ] }, { "ingredient": "morphine", "rank": 198, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Opiates (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "N02AA" ] }, { "ingredient": "doxazosin", "rank": 199, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs\". The CDC table does not include this class.", "atc": [ "C02CA" ] }, { "ingredient": "tacrolimus", "rank": 200, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "D11AH", "L04AD" ] }, { "ingredient": "polymyxin B", "rank": 203, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "A07AA", "J01XB", "S01AA", "S02AA", "S03AA" ] }, { "ingredient": "ketorolac", "rank": 206, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "M01AB", "S01BC" ] }, { "ingredient": "polyethylene glycols", "rank": 208, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A06AD" ] }, { "ingredient": "polyethylene glycols", "rank": 208, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A06AD" ] }, { "ingredient": "melatonin", "rank": 210, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics\". The CDC table does not include this class.", "atc": [ "N05CH" ] }, { "ingredient": "liothyronine", "rank": 211, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"drugs that increase the basal metabolic rate such as thyroxine\". The CDC table does not include this class.", "atc": [ "H03AA" ] }, { "ingredient": "telmisartan", "rank": 212, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Angiotensin II Receptor blockers (ARBs). Health Canada does not name this class.", "atc": [ "C09CA" ] }, { "ingredient": "colchicine", "rank": 214, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "M04AC" ] }, { "ingredient": "lansoprazole", "rank": 215, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "A02BC" ] }, { "ingredient": "linaclotide", "rank": 218, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A06AX" ] }, { "ingredient": "linaclotide", "rank": 218, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A06AX" ] }, { "ingredient": "rizatriptan", "rank": 220, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists\". The CDC table does not include this class.", "atc": [ "N02CC" ] }, { "ingredient": "erythromycin", "rank": 225, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "D10AF", "J01FA", "S01AA" ] }, { "ingredient": "dexlansoprazole", "rank": 226, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "A02BC" ] }, { "ingredient": "solifenacin", "rank": 229, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with sweating, such as anticholinergics or beta blockers\". The CDC table does not include this class.", "atc": [ "G04BD" ] }, { "ingredient": "calcium carbonate", "rank": 232, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Antacids (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A02AC", "A12AA" ] }, { "ingredient": "calcium carbonate", "rank": 232, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Antacids (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A02AC", "A12AA" ] }, { "ingredient": "levofloxacin", "rank": 233, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01MA", "S01AE" ] }, { "ingredient": "mirabegron", "rank": 236, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with sweating, such as anticholinergics or beta blockers\". The CDC table does not include this class.", "atc": [ "G04BD" ] }, { "ingredient": "minoxidil", "rank": 238, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs\". The CDC table does not include this class.", "atc": [ "C02DC", "D11AX" ] }, { "ingredient": "sucralfate", "rank": 239, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "A02BX" ] }, { "ingredient": "pramipexole", "rank": 242, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Anti-Parkinson's agents\". The CDC table does not include this class.", "atc": [ "N04BC" ] }, { "ingredient": "sennosides, USP", "rank": 244, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A06AB" ] }, { "ingredient": "sennosides, USP", "rank": 244, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A06AB" ] }, { "ingredient": "ticagrelor", "rank": 246, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Anti-platelet medications. UK Health Security Agency does not name this class.", "atc": [ "B01AC" ] }, { "ingredient": "ticagrelor", "rank": 246, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Anti-platelet medications. Health Canada does not name this class.", "atc": [ "B01AC" ] }, { "ingredient": "moxifloxacin", "rank": 254, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01MA", "S01AE" ] }, { "ingredient": "nabumetone", "rank": 269, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "M01AX" ] }, { "ingredient": "neomycin", "rank": 270, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "A01AB", "A07AA", "B05CA", "D06AX", "J01GB", "R02AB", "S01AA", "S02AA", "S03AA" ] }, { "ingredient": "penicillin V", "rank": 272, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01CE" ] }, { "ingredient": "diphenhydramine", "rank": 273, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Antihistamines with anticholinergic properties. Health Canada does not name this class.", "atc": [ "D04AA", "R06AA" ] }, { "ingredient": "guanfacine", "rank": 279, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs\". The CDC table does not include this class.", "atc": [ "C02AC" ] }, { "ingredient": "fluorouracil", "rank": 280, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies\". The CDC table does not include this class.", "atc": [ "L01BC" ] }, { "ingredient": "indomethacin", "rank": 286, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "C01EB", "M01AB", "M02AA", "S01BC" ] }, { "ingredient": "cefuroxime", "rank": 288, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01DC", "S01AA" ] }, { "ingredient": "levodopa", "rank": 293, "key": "health_canada", "direction": "guidance lists, app does not", "reason": "Health Canada lists it under \"Anti-Parkinson's agents\". The CDC table does not include this class.", "atc": [ "N04BA" ] }, { "ingredient": "lactulose", "rank": 294, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A06AD" ] }, { "ingredient": "lactulose", "rank": 294, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A06AD" ] }, { "ingredient": "tobramycin", "rank": 295, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration\". The CDC table does not include this class.", "atc": [ "J01GB", "S01AA" ] }, { "ingredient": "magnesium sulfate", "rank": 297, "key": "ukhsa", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). UK Health Security Agency does not name this class.", "atc": [ "A06AD", "A12CC", "B05XA", "D11AX", "V04CC" ] }, { "ingredient": "magnesium sulfate", "rank": 297, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Laxatives (mentioned in the page text, not the table). Health Canada does not name this class.", "atc": [ "A06AD", "A12CC", "B05XA", "D11AX", "V04CC" ] }, { "ingredient": "etodolac", "rank": 299, "key": "health_canada", "direction": "app flags, guidance does not", "reason": "The CDC lists Nonsteroidal anti-inflammatory drugs (NSAIDS). Health Canada does not name this class.", "atc": [ "M01AB" ] }, { "ingredient": "atropine", "rank": 300, "key": "ukhsa", "direction": "guidance lists, app does not", "reason": "UK Health Security Agency lists it under \"medications that interfere with sweating, such as anticholinergics or beta blockers\". The CDC table does not include this class.", "atc": [ "A03BA", "S01FA" ] } ], "rows": [ { "rank": 1, "ingredient": "atorvastatin", "status": "resolved", "atc": [ "C10AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 2, "ingredient": "metformin", "status": "resolved", "atc": [ "A10BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 3, "ingredient": "levothyroxine", "status": "resolved", "atc": [ "H03AA" ], "app_flags": true, "cdc_classes": [ { "id": "levothyroxine", "label": "Thyroid replacement: Levothyroxine", "quote": "Excessive sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "drugs that increase the basal metabolic rate such as thyroxine" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 4, "ingredient": "lisinopril", "status": "resolved", "atc": [ "C09AA" ], "app_flags": true, "cdc_classes": [ { "id": "ace_inhibitors", "label": "Angiotensin Converting Enzyme Inhibitor (ACEi)", "quote": "Decreased blood pressure, increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "ACE inhibitors" ] }, { "rank": 5, "ingredient": "amlodipine", "status": "resolved", "atc": [ "C08CA" ], "app_flags": true, "cdc_classes": [ { "id": "calcium_channel_blockers", "label": "Calcium channel blocker", "quote": "Decreased blood pressure, increased risk of fainting and falls; Electrolyte imbalance" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 6, "ingredient": "losartan", "status": "resolved", "atc": [ "C09CA" ], "app_flags": true, "cdc_classes": [ { "id": "arbs", "label": "Angiotensin II Receptor blockers (ARBs)", "quote": "Decreased blood pressure, increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 7, "ingredient": "albuterol", "status": "resolved", "atc": [ "R03AC", "R03CC" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 8, "ingredient": "metoprolol", "status": "resolved", "atc": [ "C07AB" ], "app_flags": true, "cdc_classes": [ { "id": "beta_blockers", "label": "Beta blockers", "quote": "Reduced superficial vasodilation; Decreased sweating; Reduced blood pressure, increased risk of fainting and falls" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs", "medications that interfere with sweating, such as anticholinergics or beta blockers" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 9, "ingredient": "rosuvastatin", "status": "resolved", "atc": [ "C10AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 10, "ingredient": "hydrochlorothiazide", "status": "resolved", "atc": [ "C03AA" ], "app_flags": true, "cdc_classes": [ { "id": "diuretics", "label": "Diuretics", "quote": "Electrolyte imbalance; Volume depletion, dehydration and increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "diuretics, especially loop diuretics, which can lead to dehydration and electrolyte abnormalities" ], "health_canada": true, "health_canada_phrases": [ "Diuretics" ] }, { "rank": 11, "ingredient": "omeprazole", "status": "resolved", "atc": [ "A02BC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 12, "ingredient": "gabapentin", "status": "resolved", "atc": [ "N02BF" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 13, "ingredient": "sertraline", "status": "resolved", "atc": [ "N06AB" ], "app_flags": true, "cdc_classes": [ { "id": "ssri", "label": "Selective Serotonin Reuptake Inhibitors (SSRI)", "quote": "Increased sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 14, "ingredient": "fluticasone", "status": "resolved", "atc": [ "D07AC", "R01AD", "R03BA" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 15, "ingredient": "escitalopram", "status": "resolved", "atc": [ "N06AB" ], "app_flags": true, "cdc_classes": [ { "id": "ssri", "label": "Selective Serotonin Reuptake Inhibitors (SSRI)", "quote": "Increased sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 16, "ingredient": "semaglutide", "status": "resolved", "atc": [ "A10BJ" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 17, "ingredient": "dextroamphetamine", "status": "resolved", "atc": [ "N06BA" ], "app_flags": true, "cdc_classes": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 18, "ingredient": "amphetamine", "status": "resolved", "atc": [ "N06BA" ], "app_flags": true, "cdc_classes": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 19, "ingredient": "acetaminophen", "status": "resolved", "atc": [ "N02BE" ], "app_flags": true, "cdc_classes": [ { "id": "acetaminophen", "label": "Acetaminophen", "quote": "Heat related liver injury increase risk for acetaminophen hepatoxicity" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 20, "ingredient": "pantoprazole", "status": "resolved", "atc": [ "A02BC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 21, "ingredient": "bupropion", "status": "resolved", "atc": [ "N06AX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 22, "ingredient": "amoxicillin", "status": "resolved", "atc": [ "J01CA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 23, "ingredient": "ethinyl estradiol", "status": "resolved", "atc": [ "G03CA", "L02AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 24, "ingredient": "fluoxetine", "status": "resolved", "atc": [ "N06AB" ], "app_flags": true, "cdc_classes": [ { "id": "ssri", "label": "Selective Serotonin Reuptake Inhibitors (SSRI)", "quote": "Increased sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 25, "ingredient": "trazodone", "status": "resolved", "atc": [ "N06AX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 26, "ingredient": "montelukast", "status": "resolved", "atc": [ "R03DC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 27, "ingredient": "tamsulosin", "status": "resolved", "atc": [ "G04CA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 28, "ingredient": "apixaban", "status": "resolved", "atc": [ "B01AF" ], "app_flags": true, "cdc_classes": [ { "id": "apixaban", "label": "Apixaban (mentioned in the page text, not the table)", "quote": "Toxicity from reduced clearance of medications with a narrow therapeutic index (e.g., apixaban, carbamazepine, and lithium)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 29, "ingredient": "insulin glargine", "status": "resolved", "atc": [ "A10AE" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 30, "ingredient": "simvastatin", "status": "resolved", "atc": [ "C10AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 31, "ingredient": "oxycodone", "status": "resolved", "atc": [ "N02AA" ], "app_flags": true, "cdc_classes": [ { "id": "opiates", "label": "Opiates (mentioned in the page text, not the table)", "quote": "Sedation or cognitive impairment with increased risk of falls and reduced thirst sensation (e.g., opiates, benzodiazepines, typical and atypical antipsychotic medications, antidepressants, anticonvulsants)" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration", "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 32, "ingredient": "empagliflozin", "status": "resolved", "atc": [ "A10BK" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 33, "ingredient": "furosemide", "status": "resolved", "atc": [ "C03CA" ], "app_flags": true, "cdc_classes": [ { "id": "diuretics", "label": "Diuretics", "quote": "Electrolyte imbalance; Volume depletion, dehydration and increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "diuretics, especially loop diuretics, which can lead to dehydration and electrolyte abnormalities" ], "health_canada": true, "health_canada_phrases": [ "Diuretics" ] }, { "rank": 34, "ingredient": "meloxicam", "status": "resolved", "atc": [ "M01AC" ], "app_flags": true, "cdc_classes": [ { "id": "nsaids", "label": "Nonsteroidal anti-inflammatory drugs (NSAIDS)", "quote": "Kidney injury with dehydration" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 35, "ingredient": "hydrocodone", "status": "resolved", "atc": [ "R05DA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 36, "ingredient": "tirzepatide", "status": "resolved", "atc": [ "A10BX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 37, "ingredient": "methylphenidate", "status": "resolved", "atc": [ "N06BA" ], "app_flags": true, "cdc_classes": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 38, "ingredient": "duloxetine", "status": "resolved", "atc": [ "N06AX" ], "app_flags": true, "cdc_classes": [ { "id": "snri", "label": "Serotonin and Norepinephrine Reuptake Inhibitors (SNRI)", "quote": "Increased sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 39, "ingredient": "prednisone", "status": "resolved", "atc": [ "A07EA", "H02AB" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 40, "ingredient": "carvedilol", "status": "resolved", "atc": [ "C07AG" ], "app_flags": true, "cdc_classes": [ { "id": "beta_blockers", "label": "Beta blockers", "quote": "Reduced superficial vasodilation; Decreased sweating; Reduced blood pressure, increased risk of fainting and falls" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs", "medications that interfere with sweating, such as anticholinergics or beta blockers" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 41, "ingredient": "famotidine", "status": "resolved", "atc": [ "A02BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 42, "ingredient": "ibuprofen", "status": "resolved", "atc": [ "C01EB", "G02CC", "M01AE", "M02AA", "R02AX" ], "app_flags": true, "cdc_classes": [ { "id": "nsaids", "label": "Nonsteroidal anti-inflammatory drugs (NSAIDS)", "quote": "Kidney injury with dehydration" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 43, "ingredient": "buspirone", "status": "resolved", "atc": [ "N05BE" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics", "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 44, "ingredient": "venlafaxine", "status": "resolved", "atc": [ "N06AX" ], "app_flags": true, "cdc_classes": [ { "id": "snri", "label": "Serotonin and Norepinephrine Reuptake Inhibitors (SNRI)", "quote": "Increased sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 45, "ingredient": "norethindrone", "status": "resolved", "atc": [ "G03AC", "G03DC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 46, "ingredient": "potassium chloride", "status": "resolved", "atc": [ "A12BA", "B05XA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 47, "ingredient": "tramadol", "status": "resolved", "atc": [ "N02AX" ], "app_flags": true, "cdc_classes": [ { "id": "opiates", "label": "Opiates (mentioned in the page text, not the table)", "quote": "Sedation or cognitive impairment with increased risk of falls and reduced thirst sensation (e.g., opiates, benzodiazepines, typical and atypical antipsychotic medications, antidepressants, anticonvulsants)" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration", "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 48, "ingredient": "allopurinol", "status": "resolved", "atc": [ "M04AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 49, "ingredient": "hydroxyzine", "status": "resolved", "atc": [ "N05BB" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with sweating, such as anticholinergics or beta blockers", "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 50, "ingredient": "clopidogrel", "status": "resolved", "atc": [ "B01AC" ], "app_flags": true, "cdc_classes": [ { "id": "antiplatelets", "label": "Anti-platelet medications", "quote": "Reduced superficial vasodilation" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 51, "ingredient": "ergocalciferol", 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false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 108, "ingredient": "umeclidinium", "status": "resolved", "atc": [ "R03BB" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 109, "ingredient": "methocarbamol", "status": "resolved", "atc": [ "M03BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 110, "ingredient": "diltiazem", "status": "resolved", "atc": [ "C05AE", "C08DB" ], "app_flags": true, "cdc_classes": [ { "id": "calcium_channel_blockers", "label": "Calcium channel blocker", "quote": "Decreased blood pressure, increased risk of fainting and falls; Electrolyte imbalance" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 111, "ingredient": "trimethoprim", "status": "resolved", "atc": [ "J01EA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 112, "ingredient": "thyroid (USP)", "status": "resolved", "atc": [], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 113, "ingredient": "baclofen", "status": "resolved", "atc": [ "M03BX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 114, "ingredient": "sumatriptan", "status": "resolved", "atc": [ "N02CC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 115, "ingredient": "prednisolone", "status": "resolved", "atc": [ "A01AC", "A07EA", "C05AA", "D07AA", "D07XA", "H02AB", "R01AD", "S01BA", "S01CB", "S02BA", "S03BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 116, "ingredient": "esomeprazole", "status": "resolved", "atc": [ "A02BC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 117, "ingredient": "benazepril", "status": "resolved", "atc": [ "C09AA" ], "app_flags": true, "cdc_classes": [ { "id": "ace_inhibitors", "label": "Angiotensin Converting Enzyme Inhibitor (ACEi)", "quote": "Decreased blood pressure, increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "ACE inhibitors" ] }, { "rank": 118, "ingredient": "mirtazapine", "status": "resolved", "atc": [ "N06AX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 119, "ingredient": "levetiracetam", "status": "resolved", "atc": [ "N03AX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "agents with levels affected by dehydration, such as lithium, digoxin, antiepileptics" ], "health_canada": true, "health_canada_phrases": [ "Anti-epileptics" ] }, { "rank": 120, "ingredient": "naproxen", "status": "resolved", "atc": [ "G02CC", "M01AE", "M02AA" ], "app_flags": true, "cdc_classes": [ { "id": "nsaids", "label": "Nonsteroidal anti-inflammatory drugs (NSAIDS)", "quote": "Kidney injury with dehydration" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 121, "ingredient": "tadalafil", "status": "resolved", "atc": [ "G04BE" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 122, "ingredient": "nifedipine", "status": "resolved", "atc": [ "C08CA" ], "app_flags": true, "cdc_classes": [ { "id": "calcium_channel_blockers", "label": "Calcium channel blocker", "quote": "Decreased blood pressure, increased risk of fainting and falls; Electrolyte imbalance" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 123, "ingredient": "progesterone", "status": "resolved", "atc": [ "G03DA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 124, "ingredient": "insulin degludec", "status": "resolved", "atc": [ "A10AE" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 125, "ingredient": "hydralazine", "status": "resolved", "atc": [ "C02DB" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 126, "ingredient": "azelastine", "status": "resolved", "atc": [ "R01AC", "R06AX", "S01GX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 127, "ingredient": "ipratropium", "status": "resolved", "atc": [ "R01AX", "R03BB" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 128, "ingredient": "timolol", "status": "resolved", "atc": [ "C07AA", "S01ED" ], "app_flags": true, "cdc_classes": [ { "id": "beta_blockers", "label": "Beta blockers", "quote": "Reduced superficial vasodilation; Decreased sweating; Reduced blood pressure, increased risk of fainting and falls" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as 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], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 132, "ingredient": "chlorthalidone", "status": "resolved", "atc": [ "C03BA" ], "app_flags": true, "cdc_classes": [ { "id": "diuretics", "label": "Diuretics", "quote": "Electrolyte imbalance; Volume depletion, dehydration and increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "diuretics, especially loop diuretics, which can lead to dehydration and electrolyte abnormalities" ], "health_canada": true, "health_canada_phrases": [ "Diuretics" ] }, { "rank": 133, "ingredient": "oxybutynin", "status": "resolved", "atc": [ "G04BD" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with sweating, such as anticholinergics or 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"health_canada_phrases": [] }, { "rank": 137, "ingredient": "irbesartan", "status": "resolved", "atc": [ "C09CA" ], "app_flags": true, "cdc_classes": [ { "id": "arbs", "label": "Angiotensin II Receptor blockers (ARBs)", "quote": "Decreased blood pressure, increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 138, "ingredient": "hydroxychloroquine", "status": "resolved", "atc": [ "P01BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 139, "ingredient": "vitamin B12", "status": "resolved", "atc": [ "B03BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 140, "ingredient": "nitrofurantoin", "status": "resolved", "atc": [ "J01XE" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 141, "ingredient": "sulfamethoxazole", "status": "resolved", "atc": [ "J01EC" ], "app_flags": true, "cdc_classes": [ { "id": "sulfonamides", "label": "Antibiotics: Sulfonamides", "quote": "Kidney injury risk with dehydration" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 142, "ingredient": "benzonatate", "status": "resolved", "atc": [ "R05DB" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 143, "ingredient": "isosorbide", "status": "resolved", "atc": [ "C01DA" ], "app_flags": true, "cdc_classes": [ { "id": "nitrates", "label": "Nitrates", "quote": "Worsened hypotension" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "Nitrate vasodilators" ] }, { "rank": 144, "ingredient": "methylprednisolone", "status": "resolved", "atc": [ "D07AA", "D10AA", "H02AB" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 145, "ingredient": "triamterene", "status": "resolved", "atc": [ "C03DB" ], "app_flags": true, "cdc_classes": [ { "id": "diuretics", "label": "Diuretics", "quote": "Electrolyte imbalance; Volume depletion, dehydration and increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "diuretics, especially loop diuretics, which can lead to dehydration and electrolyte abnormalities" ], "health_canada": true, "health_canada_phrases": [ "Diuretics" ] }, { "rank": 146, "ingredient": "levocetirizine", "status": "resolved", "atc": [ "R06AE" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 147, "ingredient": "ciprofloxacin", "status": "resolved", "atc": [ "J01MA", "S01AE", "S02AA", "S03AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": true, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 148, "ingredient": "atomoxetine", "status": "resolved", "atc": [ "N06BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 149, "ingredient": "docusate", "status": "resolved", "atc": [ "A06AA" ], "app_flags": true, "cdc_classes": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 150, "ingredient": "dorzolamide", "status": "resolved", "atc": [ "S01EC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 151, "ingredient": "dexmethylphenidate", "status": "resolved", "atc": [ "N06BA" ], "app_flags": true, "cdc_classes": [ { "id": "stimulants", "label": "Stimulants", "quote": "Increased body temperature (Amphetamine, Methylphenidate); Reduced sweating; Reduced dilation of skin blood vessels; Impaired heat perception (Cocaine)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 152, "ingredient": "promethazine", "status": "resolved", "atc": [ "D04AA", "R06AD" ], "app_flags": true, "cdc_classes": [ { "id": "anticholinergic_antihistamines", "label": "Antihistamines with anticholinergic properties", "quote": "Decreased sweating; Impaired thermoregulation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with sweating, such as anticholinergics or beta blockers" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 153, "ingredient": "methotrexate", "status": "resolved", "atc": [ "L01BA", "L04AX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 154, "ingredient": "donepezil", "status": "resolved", "atc": [ "N06DA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": true, "health_canada_phrases": [ "Anti-Alzheimer's agents (Cholinesterase inhibitors)" ] }, { "rank": 155, "ingredient": "desvenlafaxine", "status": "resolved", "atc": [ "N06AX" ], "app_flags": true, "cdc_classes": [ { "id": "snri", "label": "Serotonin and Norepinephrine Reuptake Inhibitors (SNRI)", "quote": "Increased sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 156, "ingredient": "ropinirole", "status": "resolved", "atc": [ "N04BC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": true, "health_canada_phrases": [ "Anti-Parkinson's agents" ] }, { "rank": 157, "ingredient": "clobetasol", "status": 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[], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 161, "ingredient": "verapamil", "status": "resolved", "atc": [ "C08DA" ], "app_flags": true, "cdc_classes": [ { "id": "calcium_channel_blockers", "label": "Calcium channel blocker", "quote": "Decreased blood pressure, increased risk of fainting and falls; Electrolyte imbalance" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 162, "ingredient": "etonogestrel", "status": "resolved", "atc": [ "G03AC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 163, "ingredient": "olanzapine", "status": "resolved", "atc": [ "N05AH" ], "app_flags": true, "cdc_classes": [ { "id": "antipsychotics", "label": "Antipsychotics", "quote": "Impaired sweating; Impaired temperature" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antipsychotics/ Neuroleptics" ] }, { "rank": 164, "ingredient": "metronidazole", "status": "resolved", "atc": [ "A01AB", "D06BX", "G01AF", "J01XD", "P01AB" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": true, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 165, "ingredient": "prazosin", "status": "resolved", "atc": [ "C02CA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 166, "ingredient": "sildenafil", "status": "resolved", "atc": [ "G04BE" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 167, "ingredient": "insulin isophane", "status": "resolved", "atc": [], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 168, "ingredient": "levonorgestrel", "status": "resolved", "atc": [ "G03AC", "G03AD" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 169, "ingredient": "evolocumab", "status": "resolved", "atc": [ "C10AX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 170, "ingredient": "dexamethasone", "status": "resolved", "atc": [ "A01AC", "C05AA", "D07AB", "D07XB", "D10AA", "H02AB", "R01AD", "S01BA", "S01CB", "S02BA", "S03BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 171, "ingredient": "mesalamine", "status": "resolved", "atc": [ "A07EC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 172, "ingredient": "memantine", "status": "resolved", "atc": [ "N06DX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 173, "ingredient": "diazepam", "status": "resolved", "atc": [ "N05BA" ], "app_flags": true, "cdc_classes": [ { "id": "benzodiazepines", "label": "Benzodiazepines (mentioned in the page text, not the table)", "quote": "Sedation or cognitive impairment with increased risk of falls and reduced thirst sensation (e.g., opiates, benzodiazepines, typical and atypical antipsychotic medications, antidepressants, anticonvulsants)" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 174, "ingredient": "lithium", "status": "resolved", "atc": [ "N05AN" ], "app_flags": true, "cdc_classes": [ { "id": "lithium", "label": "Mood stabilizer: Lithium", "quote": "Diabetes insipidus induced water loss and risk for fainting, falls; Electrolyte imbalance; Risk for toxicity in setting of dehydration because of narrow therapeutic index" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "agents with levels affected by dehydration, such as lithium, digoxin, antiepileptics", "medications that can interfere with central nervous system thermoregulation, such as neuroleptics and serotoninergic agonists" ], "health_canada": true, "health_canada_phrases": [ "Antipsychotics/ Neuroleptics", "Lithium" ] }, { "rank": 175, "ingredient": "nortriptyline", "status": "resolved", "atc": [ "N06AA" ], "app_flags": true, "cdc_classes": [ { "id": "tricyclics", "label": "Tricyclic antidepressants (TCAs)", "quote": "Decreased sweating" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with sweating, such as anticholinergics or beta blockers" ], "health_canada": true, "health_canada_phrases": [ "Antidepressants" ] }, { "rank": 176, "ingredient": "cefdinir", "status": "resolved", "atc": [ "J01DD" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 177, "ingredient": "magnesium oxide", "status": "resolved", "atc": [ "A02AA", "A06AD", "A12CC" ], "app_flags": true, "cdc_classes": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 178, "ingredient": "clotrimazole", "status": "resolved", "atc": [ "A01AB", "D01AC", "G01AF" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 179, "ingredient": "meclizine", "status": "resolved", "atc": [ "R06AE" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 180, "ingredient": "cyclosporine", "status": "resolved", "atc": [ "L04AD", "S01XA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 181, "ingredient": "tretinoin", "status": "resolved", "atc": [ "D10AD", "L01XF" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 182, "ingredient": "fluconazole", "status": "resolved", "atc": [ "D01AC", "J02AC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 183, "ingredient": "rimegepant", "status": "resolved", "atc": [ "N02CD" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 184, "ingredient": "lovastatin", "status": "resolved", "atc": [ "C10AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 185, "ingredient": "drospirenone", "status": "resolved", "atc": [ "G03AC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 186, "ingredient": "codeine", "status": "resolved", "atc": [ "R05DA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 187, "ingredient": "tiotropium", "status": "resolved", "atc": [ "R03BB" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 188, "ingredient": "temazepam", "status": "resolved", "atc": [ "N05CD" ], "app_flags": true, "cdc_classes": [ { "id": "benzodiazepines", "label": "Benzodiazepines (mentioned in the page text, not the table)", "quote": "Sedation or cognitive impairment with increased risk of falls and reduced thirst sensation (e.g., opiates, benzodiazepines, typical and atypical antipsychotic medications, antidepressants, anticonvulsants)" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 189, "ingredient": "brimonidine", "status": "resolved", "atc": [ "D11AX", "S01EA", "S01GA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 190, "ingredient": "nirmatrelvir", "status": "resolved", "atc": [], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 191, "ingredient": "ritonavir", "status": "resolved", "atc": [ "J05AE" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 192, "ingredient": "sacubitril", "status": "resolved", "atc": [], "app_flags": true, "cdc_classes": [ { "id": "arni", "label": "Angiotensin Receptor-Neprilysin Inhibitors (ARNIs), combination drug including ARB", "quote": "See ARBs. Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) may carry the same additive risk." } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 193, "ingredient": "valproate", "status": "resolved", "atc": [ "N03AG" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "agents with levels affected by dehydration, such as lithium, digoxin, antiepileptics" ], "health_canada": true, "health_canada_phrases": [ "Anti-epileptics" ] }, { "rank": 194, "ingredient": "dextromethorphan", "status": "resolved", "atc": [ "R05DA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 195, "ingredient": "nebivolol", "status": "resolved", "atc": [ "C07AB" ], "app_flags": true, "cdc_classes": [ { "id": "beta_blockers", "label": "Beta blockers", "quote": "Reduced superficial vasodilation; Decreased sweating; Reduced blood pressure, increased risk of fainting and falls" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs", "medications that interfere with sweating, such as anticholinergics or beta blockers" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 196, "ingredient": "acyclovir", "status": "resolved", "atc": [ "D06BB", "J05AB", "S01AD" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 197, "ingredient": "betamethasone", "status": "resolved", "atc": [ "A07EA", "C05AA", "D07AC", "D07XC", "H02AB", "R01AD", "R03BA", "S01BA", "S01CB", "S02BA", "S03BA" ], "app_flags": false, "cdc_classes": [], "storage_only": true, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 198, "ingredient": "morphine", "status": "resolved", "atc": [ "N02AA" ], "app_flags": true, "cdc_classes": [ { "id": "opiates", "label": "Opiates (mentioned in the page text, not the table)", "quote": "Sedation or cognitive impairment with increased risk of falls and reduced thirst sensation (e.g., opiates, benzodiazepines, typical and atypical antipsychotic medications, antidepressants, anticonvulsants)" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration", "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 199, "ingredient": "doxazosin", "status": "resolved", "atc": [ "C02CA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 200, "ingredient": "tacrolimus", "status": "resolved", "atc": [ "D11AH", "L04AD" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 201, "ingredient": "dupilumab", "status": "resolved", "atc": [ "D11AH" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 202, "ingredient": "enalapril", "status": "resolved", "atc": [ "C09AA" ], "app_flags": true, "cdc_classes": [ { "id": "ace_inhibitors", "label": "Angiotensin Converting Enzyme Inhibitor (ACEi)", "quote": "Decreased blood pressure, increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "ACE inhibitors" ] }, { "rank": 203, "ingredient": "polymyxin B", "status": "resolved", "atc": [ "A07AA", "J01XB", "S01AA", "S02AA", "S03AA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that cause diarrhoea or vomiting, such as colchicine, antibiotics and opiates, which can lead to dehydration" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 204, "ingredient": "anastrozole", "status": "resolved", "atc": [ "L02BG" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 205, "ingredient": "torsemide", "status": "resolved", "atc": [ "C03CA" ], "app_flags": true, "cdc_classes": [ { "id": "diuretics", "label": "Diuretics", "quote": "Electrolyte imbalance; Volume depletion, dehydration and increased risk of fainting and falls; Reduced thirst sensation" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "diuretics, especially loop diuretics, which can lead to dehydration and electrolyte abnormalities" ], "health_canada": true, "health_canada_phrases": [ "Diuretics" ] }, { "rank": 206, "ingredient": "ketorolac", "status": "resolved", "atc": [ "M01AB", "S01BC" ], "app_flags": true, "cdc_classes": [ { "id": "nsaids", "label": "Nonsteroidal anti-inflammatory drugs (NSAIDS)", "quote": "Kidney injury with dehydration" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 207, "ingredient": "nitroglycerin", "status": "resolved", "atc": [ "C01DA", "C05AE" ], "app_flags": true, "cdc_classes": [ { "id": "nitrates", "label": "Nitrates", "quote": "Worsened hypotension" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs" ], "health_canada": true, "health_canada_phrases": [ "Nitrate vasodilators" ] }, { "rank": 208, "ingredient": "polyethylene glycols", "status": "resolved", "atc": [ "A06AD" ], "app_flags": true, "cdc_classes": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 209, "ingredient": "flecainide", "status": "resolved", "atc": [ "C01BC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 210, "ingredient": "melatonin", "status": "resolved", "atc": [ "N05CH" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "drugs that alter states of alertness, such as hypnotics, anxiolytics and analgesics" ], 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"ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 242, "ingredient": "pramipexole", "status": "resolved", "atc": [ "N04BC" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": true, "health_canada_phrases": [ "Anti-Parkinson's agents" ] }, { "rank": 243, "ingredient": "calcitriol", "status": "resolved", "atc": [ "A11CC", "D05AX" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 244, "ingredient": "sennosides, USP", "status": "resolved", "atc": [ "A06AB" ], "app_flags": true, "cdc_classes": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal 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false, "ukhsa": true, "ukhsa_phrases": [ "diuretics, especially loop diuretics, which can lead to dehydration and electrolyte abnormalities" ], "health_canada": true, "health_canada_phrases": [ "Diuretics" ] }, { "rank": 251, "ingredient": "labetalol", "status": "resolved", "atc": [ "C07AG" ], "app_flags": true, "cdc_classes": [ { "id": "beta_blockers", "label": "Beta blockers", "quote": "Reduced superficial vasodilation; Decreased sweating; Reduced blood pressure, increased risk of fainting and falls" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with cardiovascular responses such as antihypertensives and antianginal drugs", "medications that interfere with sweating, such as anticholinergics or beta blockers" ], "health_canada": true, "health_canada_phrases": [ "Calcium channel blockers & beta blockers" ] }, { "rank": 252, "ingredient": "guaifenesin", "status": "resolved", "atc": [ "R05CA" ], "app_flags": false, 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"app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 292, "ingredient": "carbidopa", "status": "resolved", "atc": [], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 293, "ingredient": "levodopa", "status": "resolved", "atc": [ "N04BA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": true, "health_canada_phrases": [ "Anti-Parkinson's agents" ] }, { "rank": 294, "ingredient": "lactulose", "status": "resolved", "atc": [ "A06AD" ], "app_flags": true, "cdc_classes": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of 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"rank": 297, "ingredient": "magnesium sulfate", "status": "resolved", "atc": [ "A06AD", "A12CC", "B05XA", "D11AX", "V04CC" ], "app_flags": true, "cdc_classes": [ { "id": "laxatives", "label": "Laxatives (mentioned in the page text, not the table)", "quote": "Volume depletion, hypotension, or reduced cardiac output with increased risk of fainting and falls, as a result of reduced renal blood flow and/or kidney injury from nephrotoxic drugs (non-steroidal anti-inflammatory drugs [NSAIDs], diuretics, beta blockers, TCAs, laxatives)" } ], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 298, "ingredient": "chlorpheniramine", "status": "resolved", "atc": [ "R06AB" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": false, "ukhsa_phrases": [], "health_canada": false, "health_canada_phrases": [] }, { "rank": 299, "ingredient": "etodolac", "status": "resolved", "atc": [ "M01AB" ], "app_flags": true, "cdc_classes": [ { "id": "nsaids", "label": "Nonsteroidal anti-inflammatory drugs (NSAIDS)", "quote": "Kidney injury with dehydration" } ], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that can impair renal function, such as certain antimicrobials, immunosuppressants, non-steroidal anti-inflammatories, anti-ulcer agents and chemotherapies" ], "health_canada": false, "health_canada_phrases": [] }, { "rank": 300, "ingredient": "atropine", "status": "resolved", "atc": [ "A03BA", "S01FA" ], "app_flags": false, "cdc_classes": [], "storage_only": false, "sun_only": false, "ukhsa": true, "ukhsa_phrases": [ "medications that interfere with sweating, such as anticholinergics or beta blockers" ], "health_canada": false, "health_canada_phrases": [] } ], "limitation": "This measures agreement with national guidance, not clinical outcomes." }